Clefts of the lip, alveolus, and palate are among the most common craniofacial birth abnormalities found in both humans and animals. Traditional treatments, such as autogenous bone grafts, have long been regarded as the gold standard. However, these methods have substantial disadvantages, including limited bone availability and donor-site problems such as post-operative pain, changes in sensation, and the risk of infections and scarring. Fortunately, recent approaches in cell therapy and tissue engineering provide promising solutions to these issues. One interesting strategy is to use a gelatin sponge scaffold combined with cultured stem cells to repair cleft alveoli in dogs. In this blog, we’ll explore how combining these innovative approaches particularly utilizing a gelatin sponge scaffold with cultured stem cells, can revolutionize the treatment of craniofacial defects in dogs. Role of Gelatin Sponge, Cell therapy, and Tissue Engineering Gelatin Sponge Scaffold: The gelatin spon